The game introduced a more traditional grappling system while retaining the series’ fast game-play. In this new grappling system also included were body damage meters, individual character scales that consisted of stats such as strength, endurance and speed, and submission meters for both the person applying the move and the person breaking out of the move. As well as the ability to break the submission hold when being close to the ropes. This game marks the first time the Elimination Chamber and the Bra and Panties Match would be featured in a wrestling game.
The game features a number of wrestlers who were members of the WWE roster at the time. This would be the final Smack-Down!-branded game to feature Brock Lesnar, Val Venis, and Rikishi, as well as the only WWE licensed game to feature Ultimo Dragon and Sean O’Haire as playable characters. It is also the first game in the Smack-Down! series to have John Cena, Batista, Chavo Guerrero and Rey Mysterio as playable characters. This also marks the final time that Stone Cold Steve Austin and The Rock would appear in a Smack-Down! game as non-legends. Also it is the last game to feature Undertaker before he dropped his biker gimmick and the first game to depict Kane without his mask.